Cisplatin-induced apoptosis
WebCisplatin-induced nuclear DNA (nDNA) damage in dorsal root ganglion (DRG) neurons has been thoroughly investigated. Cisplatin covalently binds to nuclear DNA (nDNA) inducing DNA damage and apoptosis. Cisplatin-induced DNA damage up-regulates p53 and induces cell cycle changes in DRG neurons. WebJan 18, 2016 · Cisplatin induces apoptosis in renal tubular cells Previous studies have suggested that cisplatin might induce apoptosis in renal tubular epithelial cells 8. In our study, NRK-52E cells...
Cisplatin-induced apoptosis
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WebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was …
WebThe role of intra- and extracellular pH in apoptosis induction was investigated. Activation of caspase-3 and DNA ladder formation were used to monitor the apoptotic response. … WebSilencing STING by siRNA rescued HaCaT cells from UVB or cisplatin-induced apoptosis. NF-κB, one of the major downstream components of STING pathway, which usually regulates the classical STING apoptotic pathway, was translocated to nucleus in the HaCaT cells irradiated with UVB. This translocation was attenuated by STING silencing.
WebNov 3, 2024 · Purpose The nephrotoxicity caused by cisplatin severely limits the application and affects related platinum-based therapeutics. Neferine is a dibenzylisoquinoline alkaloid extracted from a Chinese … WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin …
WebSep 1, 2024 · Cisplatin is globally used for the treatment of human malignancies. Despite its efficacy, cisplatin use is associated with severe side effects, such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity (cisplatin-induced nephrotoxicity; CIN).
WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … cyhi the princeWebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative role of semaglutide's against cisplatin- induced cardiotoxicity and its relation to mitochondrial functions, dynamics, biogenesis, apoptosis, and redox status pathways. cyhi the prynce downloadWebCisplatin-induced apoptosis in BUMPT cells. (A) BUMPT cells were untreated or treated with 40 μ mol/L cisplatin for 20 h. Cell morphology was recorded by phase- contrast microscopy (10 × ). (B)... cyhi the prynce mp3 downloadWebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … cyhltdWebMay 1, 2008 · Cisplatin activates both intrinsic mitochondrial pathway (blue) and extrinsic death receptor pathway (green) of apoptosis. In addition, ER stress may also be induced (gray). Activation of these pathways leads to caspase-dependent or … cyh kids healthWebFor example, cisplatin induces apoptosis via ROS overgeneration in osteosarcoma MG-63 cell line , methotrexate triggers cell death by upregulating ROS production in osteosarcoma U-2 OS cells , and carvacrol triggers ROS-dependent apoptosis to suppress proliferation in prostate cancer and lung adenocarcinoma cell lines . cyhi the prynce royal flush 2WebCisplatin forms inter- and intrastrand crosslinked DNA adducts and its cytotoxicity is mediated by propagation of DNA damage recognition signals to downstream pathways … cyhl77.com